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Food-Drug & Drug-Drug Interactions

Understanding and predicting modified drug effects due to co-adminisration with food and other drugs.

Administering a drug together with a meal or on an empty stomach may enhance, decrease or not impact the release of the Active Pharmaceutical Ingredient (API) from its formulations.

The same applies to co-administered drugs, which impact the luminal gastrointestinal environment and therewith the local physical chemical conditions to release the API. Understanding and predicting such effects will inform and guide your formulation strategy to produce high potential formulation candidates, which successfully pass clinical phases.

In TIM, we can:

  • Accurately mimic the gastrointestinal luminal conditions with and without the administration of actual foods (e.g. the FDA recommended High Fat Meal)
  • Simulate co-administration of Proton Pump Inhibitors (PPIs) while altering each parameter (gastric emptying, pH profiles, site specific enzyme secretion levels, etc.)

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